Neurobiology of Disease Activity Parameters of Subthalamic Nucleus Neurons Selectively Predict Motor Symptom Severity in Parkinson’s Disease
نویسندگان
چکیده
Andrew Sharott,1,2 Alessandro Gulberti,1 Simone Zittel,3,4 Adam A. Tudor Jones,2 Ulrich Fickel,1 Alexander Münchau,3,4 Johannes A. Köppen,5 Christian Gerloff,3 Manfred Westphal,5 Carsten Buhmann,3 Wolfgang Hamel,5 Andreas K. Engel,1 and Christian K.E. Moll1 1Department of Neurophysiology and Pathophysiology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany, 2Medical Research Council Anatomical Neuropharmacology Unit, Department of Pharmacology, University of Oxford, Oxford OX1 3TH, United Kingdom, 3Department of Neurology, University Medical Center Hamburg-Eppendorf, 20246 Hamburg, Germany, 4Department of Pediatric and Adult Movement Disorders and Neuropsychiatry, Institute of Neurology, University Medical Center Schleswig-Holstein, Campus Lübeck, 23538 Lübeck, Germany, and 5Department of Neurosurgery, University Medical Centre Hamburg-Eppendorf, 20246 Hamburg, Germany
منابع مشابه
The Effects of Bilateral Subthalamic Nucleus Stimulation on Cognitive and Neuropsychiatric Functions in Parkinson’s Disease: A Case-Control Study
Introduction: Parkinson’s disease is one of the most disabling diseases which by electrode implantation and stimulation of subthalamic nucleus (STN), much progress has been made in the treatment of drug resistant patient. This new method of neurosurgery may have some neuropsychological side effects on the patients. The main aim of this study is to evaluate the effects of this kind of treatment ...
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Chronic dopamine depletion in Parkinson's disease leads to progressive motor and cognitive impairment, which is associated with the emergence of characteristic patterns of synchronous oscillatory activity within cortico-basal-ganglia circuits. Deep brain stimulation of the subthalamic nucleus is an effective treatment for Parkinson's disease, but its influence on synchronous activity in cortico...
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Shoichi A. Shimamoto,1* Elena S. Ryapolova-Webb,1* Jill L. Ostrem,2 Nicholas B. Galifianakis,2,3 Kai J. Miller,4 and Philip A. Starr1,3 Departments of 1Neurological Surgery and 2Neurology, University of California, San Francisco, California 94143, and 3Parkinson’s Disease Research, Education, and Care Center, San Francisco Veteran’s Affairs Medical Center, San Francisco, California 94143-0114, ...
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The advance of Parkinson’s disease is associated with the existence of abnormal oscillations within the basal ganglia with frequencies in the beta band (13–30 Hz). While the origin of these oscillations remains unknown, there is some evidence suggesting that oscillations observed in the basal ganglia arise due to interactions of two nuclei: the subthalamic nucleus (STN) and the globus pallidus ...
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